Sildenafil, Tadalafil, Vardenafil

Pulmonary Hypertension Treatment

Adult Dose

Sildenafil pills contain 20, 25,50 or 100 mg of active component. The smallest dosage is used for pulmonary hypertension treatment, as the pills must be taken from 4 to 6 times a day. Sildenafil can also be administered in injections (10 mg 3 times a day). In this case 10 mg if injected Sildenafil are equal to a 20 mg oral dose.

Pediatric Dose

Under 1 yr
0.3 to 2 mg/kg/dose every 6-24 hours. The pediatricians have not come to a unanimous opinion and individual dosage is recommended.

Over 1yr
0.25 to 0.5 mg/kg orally every 4 to 8 hours.

Erectile Dysfunction Treatment

Sildenafil Adult Dose

Recommended initial dose for adults is 50 mg orally, 1 hour prior to sexual activity, max 1 dose per day. Maintenance: depending on the effect and state of health – 25 to 100 mg orally ½ – 4 hours before sexual activity.

Geriatric Dose

No more than 25 mg 1 hour before the anticipated sexual activity.

Sildenafil, Tadalafil, Vardenafil all belong to a new generation of phosphodiesterase type 5 inhibitors and are used for arterial hypertension and erectile dysfunction treatment. Which if them to choose if you suffer from impotence? As far as ED treatment is concerned, all these PDF5 inhibitors are similar in use and dosage, they are absolutely interchangeable, differences lie in the sphere of side-effects and speed of action.

Sildenafil and vardenafil affect PDE6 found in the eye, so blurred vision is a common side-effect of these drugs. If you have problems with eye-sight, choose tadalafil instead. PDE1 is the enzyme found in brain and heart and tadalafil has also a weaker influence on it. If you have problems with heart or are prone to tachycardia, choose tadalafil.

Tadalafil also shows better performance as far as its work and life-span is concerned. It starts to work in 20 min and its effect can lasts for up to 36 hours, while for sildenafil and vardenafil the figures respectively are: 40 min – 4 hours; an hour – 12hours+. Remember that all these drugs lower blood pressure, so consult your doctor if you suffer from hypotension.

Description

Sildenafil is an ED treatment sold under different names, the most famous one – Viagra. It was created by British scientists as a pulmonary arterial hypertension treatment and was brought to the USA by the company Pfizer. Sildenafil is used for erectile dysfunction, pulmonary hypertension and altitude sickness treatments and have shown amazing results in all cases.

Action

Sildenafil works as an enzyme delaying the degradation of cGMP. cGMP regulates all the processes connected with the blood flow to the penis. Thus, preventing the degradation of cGMP, sildenafil stimulates blood flow in the body and has a rejuvenating and a revitalizing effect. A great plus of sildenafil as an ED treatment is that it can be used in all settings, even when a person has problems with cardio-vascular system (in this case the consultation with your therapist is obligatory!) or is ill with diabetes.

Dosage

Each pill of Viagra (or the pill under another TM) can contain “25″, “50″ or “100″ of sildenafil. It’s taken once a day, 4 hours prior to sex. When used for pulmonary hypertension treatment, sildenafil is taken 3 times a day (the dosage – 20 mg a time).

Side-effects

The most common side-effects of sildenafil are: headache, blurred vision, nasal congestion, flushing and dyspepsia. They take place in case of overdosing, allergy to sildenafil or problems with health. In the most serious cases hearing loss, severe hypotension, myocardial infarction, stroke or nonarteritic anterior ischemic optic neuropathy can occur.

Contraindications

Always read the instruction before taking sildenafil! Consult your doctor in case you have any problems with health, which
In which cases you are not recommended to take sildenafil:
• If you take nitric oxide donors
• have cardiovascular risk factors
• you have a severe impairment in renal function, degenerative retinal disorders, hypotension or have had a heart attack or a stroke not long ago
• you have decreased liver function

Description

Vardenafil, known under the name Levitra is a PDE5 inhibitor used as an alternative to sildenafil in ED treatment. The main pharmaceutical companies selling Levitra: SP, Bayer AG, GSK.

Action

Vardenafil has the same indications and contraindications, as all PDE5 inhibitors. They help to increase the blood stream to the genital area and help to cure erectile dysfunction and pulmonary hypertension. They can be used as a part of the complex treatment or separately, but in any case, if you want to buy vardenafil or other PDE5 inhibitors, a consultation with your therapists is needed.

Dosage

Vardenafil is sold in the form of 2.5 mg, 5 mg, 10 mg, and 20 mg orange pills. 10 mg of vardenafil are the equivalent of 50 mg of sildenafil, so be careful about the dosage if you use different PDE5 inhibitors. The average daily dosage of vardenafil when used for ED treatment – 10 mg a day, taken 1-2 hours before the sexual intercourse.

Side-effects

The list of the side effects includes all the complications common for PDE5 inhibitors: blurred vision, loss of hearing, chest pain, headache, heart attacks, strokes, etc. Read the instruction carefully before using vardenafil!

Contraindications

The list of contraindications includes all the typical problems with heart or cardiovascular system or allergies to the medicine. You have to avoid vardenafil in case you have has a stroke, are prone to heart attacks, suffer from decreased liver function or have other contraindication (see the list above or read the instruction to read more).

Description

Tadalafil is another PDE5 inhibitors sold under the TM Cialis or Adcirca. Cialis is used for erectile dysfunction treatment, while Adcirca is taken in case of pulmonary arterial hypertension. It was created by ICOS Corporation and was primarily sold by its daughter company. Tadalafil is also manufactured by the Indian pharmaceutical company Cipla under the trade mark Tadacip.

Action

Tadalafil is a phosphodiesterase type 5 inhibitor. PDE5 inhibitors block the the degradative action of phosphodiesterase type 5, thus preventing the degradation of cyclic GMP. Cyclic GMP is a cyclic nucleotide, which plays an essential role for the work of smooth muscles. In plain words, Tadalafil has a supportative effect of muscles and blood vessels in the genital area, which are responsible for form erection.

Dosage

The recommended dosage of Cialis, when taken for ED treatment, is 10 mg. Depending on the drug efficiency or personal tolerance pof the drug, the dosage can be decreased by 5 mg or increased up to 20 mg. You should take Cialis once a day, 1 hour before sexual activity. If you want to take Cialis on a daily basis, the recommended dosage is 2, 5 mg a day. The individual dosage depends on the medical conditions you have, so read the instruction carefully or consult your doctor for more details.

Side-effects

Can cause hypotension (low blood pressure), blurred vision, headache, dizziness, vomiting and heart attacks. Serious side effects are rare, but if you have any problems with health, consult your doctor first!

Contraindications

You should avoid taking tadalafil if you are having a course of nitrate medication or are not recommended to have sexual intercourses due to a risk heart attack risk or other problems with heart or blood vessels. Consult your doctor if you have problems with liver, kidneys or other internals.